The GSEV Annual Meeting will again take place in Frankfurt (Main) and is jointly organised with the IGLD Network
Please add the date to your agendas - more information will follow here or on the IGLD2019 webpage.
GSEV was invited by the International Society of Biomarkers and Oncology (ISOBM)
President Vivian Barak and Secretary Stefan Holdenrieder) to contribute a special session on Extracellular Vesicles to its 45th International ISOBM Conference from 24th to 27th of November in Hamburg. Although the main topic of the meeting was cancer biomarkers, other aspects including cancer biology, molecular therapeutics, immunotherapy and cancer screening were discussed at the conference. The GSEV session on Extracellular Vesicles (chaired by vice-president Eva-Maria Krämer-Albers) had the intention to underscore the potential of EVs as carriers of diverse cancer biomarkers and to strengthen the interaction between our societies. An Hendrix (Ghent University) started out with an excellent presentation stressing the importance of standardized EV-analysis in biomarker research. Furthermore, Irina Nazarenko (University Hospital Freiburg) introduced new nanotechnology devices to recover EVs from cultured cells that appear to mimic more closely the physiological state. Christoph Kahlert (University Hospital Dresden) reported on circulating EVs that carry glypican-1 and DNA and exhibit remarkable specificity and sensitivity for diagnosis of pancreatic cancer. Finally, Michael Pfaffl (Technical University, Munich) emphasized the importance of the newly released MISEV guidelines and the control of pre-analytical parameters for miRNA-analysis of blood-derived EVs. He identified miRNA profiles characterizing stages of sepsis and also provided links to the biology behind these markers relevant for the disease. The presentations were followed by lively discussions indicating that EVs are a hot topic in the field of cancer biomarkers. In summary, the session illustrated that exchange between the GSEV and ISOBM will benefit to the development of the field. Both societies see this as a start of further collaboration and expressed their intention to further strengthen the interaction.
From 15-16th of November the GSEV was holding its 1st Autumn Meeting at the Philipps-University Marburg.
Following the invitation of Elke Pogge von Strandmann and the organizing committee, 100 participants spend 2 days discussing their newest EV research in the area of EV in cancer and immunology, in development and in therapy. With a first part dedicated to proper analysis of EV, a keynote lecture of Pascale Zimmermann from Marseille and 6 invited speakers, the atmosphere was very stimulating, with a lot of interaction from junior researchers in discussion, poster flash talks and the poster session in the evening with finger food. From 12 short talks and 25 posters, the organizing committee selected Alexandra Hager from Munich for the best talk prize and Kirstin Hobiger for the best poster prize. Thanks everyone for their contribution!
Next year's GSEV autumn meeting will be held by Michael Pfaffl and colleagues from the Austrian society of EV in Munich from 28-29th of November 2019, we look forward to seeing you there.
Please see a few impressions of the symposium below.
November 28-29, 2019
GSEV was present at the Annual Meeting of the International Society for Extracellular Vesicles in Barcelona in May 2018 - see an update and a few impressions below!
A few weeks have come and gone, and after gathering our thoughts and sifting through our notes, we’d like to provide the community with a quick summary report on ISEV2018.
To begin with: Even though everybody was happy that, out of all places, sunny Barcelona was selected for ISEV’s 7th annual meeting, the weather was a huge surprising factor. It was usually rather cold, rainy and windy around the conference center. Seeing it from a positive perspective, it was very easy to stay inside all day and listen to talks – no distractions by means of sunny walks at Park Güell, sangria after visiting la Sagrada Familia or café con leche.
GSEV had a strong presence at the meeting, bringing members from Essen, Marburg, Mainz, Munich, Heidelberg, Freiburg and elsewhere. As usual, participants of the German delegation joined forces quickly and set out to explore Barcelona (after enjoying packed 12-hour days of EV science, of course!). Scientists from all branches of the field gathered in the city’s restaurants and pubs, reconnected with colleagues and got to know each other better. Over tapas and beer, it was instantly clear: these people are great – it’s good to be here!
Similarly, more and more national EV societies start sprouting worldwide, many of which presented themselves at ISEV’s evening events. As these societies are often founded by members of the former COST initiative for a European Network on Microvesicles and Exosomes in Health and Disease (ME-HAD), many local organizers know each other very well, paving the way for active collaborations among the different national societies, e.g. in transnational collaboration projects. While the field is growing rapidly (it was the first annual meeting with more than 1000 participants), the community is still close-knit and familial, both on the international and German level.
Boosted by the ever growing interested in EVs, more and more biotech, diagnostic and equipment companies team up with researchers and societies. As evidenced in the industrial exhibition and sponsor talks, these alliances, and the bottom-up feedback from researchers in the field, lead to the development of extremely useful tools, which will ultimately propel EV science forward. While previous meetings were heavily focused on advances in bulk EV characterization, the trend now seems to move towards sophisticated and ultra-pure methods for EV isolation as well as high-resolution phenotyping of individual vesicles.
Back to the meeting itself: Headed by Juan Falcón-Pérez, the Local Organizing Committee together with ISEV did a great job putting together an agenda that covered an immense breadth of vesicle research. Dozens of talks and hundreds of posters captured everything from A(rgonaute proteins – should they be present in EVs or do we regard them as contaminants?) to Z(etaView: now available as TwinNTA, providing two lasers in one device). After an opening ceremony with opera singers and a live piano (you don’t get that at most conferences!), ISEV2018 was on, featuring four days with more highlights than could be recounted here.
Three parallel tracks of symposium sessions were interspersed with plenary talks by scientific heavyweights such as Graça Raposo (reflecting on the cell biology of extracellular vesicles), Mina Bissell (urging researchers to refuse dogma and start thinking outside the box) and Nobel Laureate Randy Shekman, who brought up thought-provoking ideas about the mechanisms of RNA sorting into EVs. Additional highlights included the 3D virtual animation on extracellular vesicles presented by Dave Carter (now available on YouTube) and the MISEV II initiative that all ISEV members were encouraged to participate in. We are very excited about the upcoming results.
GSEV members were not only passive attendants at the meeting, but also contributed in various ways: our president Bernd Giebel summed up one at the educational sessions, chaired the symposium session on Tissue Injury and Repair and displayed his expertise on Leukemia EVs during Saturday’s Meet the Expert Session. Additionally, he introduced GSEV at the Meet the National Societies event. The vice president, Eva-Maria Krämer-Albers, chaired Mina Bissel’s keynote lecture and a poster session, and presented her work on using transgenic mouse models to elucidate the spatio-temporal intricacies of glia to neuron exosome transfer. GSEV’s executive director Irina Nazarenko also served as session chair and gave a talk about her work on the clinical relevance of mutated, oncogenic nucleic acids in various EV subtypes. Martin Auber, a graduate student in Krämer-Albers’ lab, received a well-deserved poster prize (cheers!) for his research on how miRNAs from serum-free media supplements co-purify with EVs, potentially skewing experiments on cell culture-derived vesicles. Last but not least, a couple of other GSEV members presented their work on posters and in selected abstract talks.
Preceded by the Education Day and rounded off with numerous additional events (Meet the Experts, Meet the Journal Editors, Satellite Events, a luncheon for young researchers’ career development and many more), ISEV2018 certainly raised the bar for next year’s meeting in Kyoto, Japan. Hasta entonces and すぐに会いましょう.
ISEV Position papers - GSEV reccomends reading these manuscripts published by the International Society for Extracellular Vesicles (full text access in the member area)
German Society for Extracellular Vesicles
The kick-off meeting for the new German network on EVs was held on 2 March 2017 in a parallel session of the 2017 IGLD Meeting in Düsseldorf.
The EV group Applied Tumor Biology (ATB) at University Hospital Heidelberg deciphers the molecular fingerprint and function of EVs derived from microsatellite-unstable (MSI) tumors.